Supporting Research

1. Milk Thistle research references.
2. Artichoke research references.
3. Green Tea Leaf research references.

Milk Thistle

Bhatia N, Zhao J, Wolf DM, Agarwal R. Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin. Cancer Lett. 1999;147(1-2):77-84.

Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; 2000:257-263.

Bokemeyer C, Fels LM, DunnT, et al. Silibinin protects against cisplatin-induced nephrotoxicity without compromising cisplatin on isosfamide anti-tumor activity. Br J Cancer. 1996;74:2036–2041.

Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications; 1998:103-104.

Campos R, Garrido A, Guerra R, et al. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Med. 1989;55:417–419.

Feher J, Deak G, Muzes G, Lang I, Neiderland V, Nekan K, et al. Hepatoprotective activity of silymarin therapy in patients with chronic alcoholic liver disease. Orv Hetil. 1990;130:51.

Ferenci P, Dragosics B, Dittrich H, Frank H., Benda L, Lochs H, et al. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J Hepatol. 1989;9:105-113.

Fintelmann V. Modern phytotherapy and its uses in gastrointestinal conditions. [Review]. Planta Med. 1991;57(7):S48-52.

Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol. 1998;93:139–43.

Gaedeke J, Fels LM, Bokemeyer C, et al. Cisplatin nephrotoxicity and protection by silibinin. Nephrol Dial Transplant. 1996;11:55–62.

Giese LA. A study of alternative health care use for gastrointestinal disorders. Gastroenterol Nurs. 2000;23(1):19-27.

Jiang C, Agarwal R, Lu J. Anti-angiogenic potential of a cancer chemopreventive flavonoid antioxidant, Silymairn: inhibition of key attributes of vascular endothelial cells and angiogenic cytokine secretion by cancer epithelial cells. Biochem Biophys Res Commun. 2000;276:371-378.

Krecman V, Skottova N, Walterova D, Ulrichova J, Simanek V. Silymarin inhibits the development of diet-induced hypercholesterolemia in rats. Planta Med. 1998;64(2):138-142.

Low Dog T. Traditional and alternative therapies for breast cancer. Altern Ther Health Med. 2001;7(3):36-47.

Luper S. A review of plants used in the treatment of liver disease: part 1. [Review].
Altern Med Rev. 1998;3(6):410-421.

Mourelle M, Favari L. Silymarin improves metabolism and disposition of aspirin in cirrhotic rats. Life Sci. 1988;43:201–207.

Palasciano G, Portincasa P, Palmieri V, Ciani D, Vendemiale G, Altomare E. The effect of silymarin on plasma levels of malon-dialdehyde in patients receiving long-term treatment with psychotropic drugs. Curr Therapeut Res. 1994;55(5):537-545.

Rotblatt M, Ziment I. Evidence-Based Herbal Medicine. Philadelphia, PA: Hanley & Belfus, Inc; 2002:266-271.

Scanbia G, De Vincenzo RD, Ranelletti FO, et al. Antiproliferative effect of Silybin on gynaecological malignancies: synergism with cisplatin an doxorubicin. Eur J Cancer. 1996;32A(5):877-882.

Silybum marianum (Milk Thistle). Alt Med Rev. 1999;4(4):272-274.

Valenzuela A, Lagos C, Schmidt K, et al. Silymarin protection against hepatic lipid peroxidation induced by acute ethanol intoxication in the rat. Biochem Pharmacol. 1985;34(12):2209–2212.

von Schonfeld J, Weisbrod B, Muller MK. Silibinin, a plant extract with antioxidant and membrane stabilizing properties, protects exocrine pancreas from cyclosporin A toxicity. Cell Mol Life Sci. 1997;53(11–12):917–920.

White L, Mavor S. Kids, Herbs, Health. Loveland, Colo: Interweave Press; 1998:22, 36.

Zi X, Feyes DK, Agarwal R. Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cyclins. Clin Cancer Res. 1998;4(4):1055-1064.

Zi X, Mukhtar H, Agarwal R. Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promoter TNF-alpha. Biochem Biophys Res Commun. 1997;239(1):334–339.

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